fashion wealth – Replica Christian Louboutin Store http://replicachristianlouboutinstore.com/ Thu, 25 Nov 2021 05:24:29 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://replicachristianlouboutinstore.com/wp-content/uploads/2021/06/icon-39.png fashion wealth – Replica Christian Louboutin Store http://replicachristianlouboutinstore.com/ 32 32 The biggest differences between the original and the reboot https://replicachristianlouboutinstore.com/the-biggest-differences-between-the-original-and-the-reboot/ Wed, 24 Nov 2021 21:30:00 +0000 https://replicachristianlouboutinstore.com/the-biggest-differences-between-the-original-and-the-reboot/ Josh Schwartz and Stéphanie Savage Gossip Girl achieved cult status in its iconic first run of 2007-2012. The team, along with writer, producer and now showrunner Joshua Safran, have decided to bring back the magic of the series in 2021 with a new rebooted version. While the ubiquitous blogger still follows the lives of wealthy […]]]>


Josh Schwartz and Stéphanie Savage Gossip Girl achieved cult status in its iconic first run of 2007-2012. The team, along with writer, producer and now showrunner Joshua Safran, have decided to bring back the magic of the series in 2021 with a new rebooted version. While the ubiquitous blogger still follows the lives of wealthy Upper East Side teens, that’s pretty much where the similarities between the two shows end.

RELATED: Gossip Girl Relationships as Taylor Swift Songs

After nearly a decade, it’s no surprise that several things are changing in the Gossip Girl to restart. Aside from the new gang, the tone of the show and the personalities of the new neighborhood kids are quite different from the days of Blair, Serena, Chuck, Dan, and Nate. A lot of other things also stand out as being very different from the original show.


9 The diversity of actors and characters

Gossip Girl 2021 reboot cast sits on New York City steps

The original show had a mostly straight and white cast of characters with the exception of a few supporting characters, like Vanessa and Nelly Yuki. The reboot changes that with a much more diverse portrayal that viewers can relate to.

Main cast members Jordan Alexander, Whitney Peak, and Evan Mock are talented POC actors who play Julien Calloway, Zoya Lott, and Aki Menzies – some of the reboot’s best characters. Transgender actress Zión Moreno stars Luna La, the show’s first trans character, and Thomas Doherty plays Max Wolfe who identifies as pansexual. These additions to the cast bring much-needed diversity to a series that clearly lacked POC and LGBTQ + representation.

8 The characters’ perspective on wealth and privilege

New Gossip Girl made a significant change in the series by making the Gen-Z children of Constance Billard and St. Jude much more attuned to the reality of their privilege. While that doesn’t stop them from partying, characters like Obie and Zoya talk about their origins.

Overall, they’re much more socially aware than the original Queen B Blair, Serena, or Chuck ever were about their charmed lives. The original characters often took off in private jets to exotic locations, spent huge sums of money on trivial things with no ulterior motives, and amassed more wealth when they already had so much.

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7 The identity of Gossip Girl (and its revelation)

Gossip girl reboots Gossip girl reveals Dan Humphrey Kate

Perhaps the biggest plot twist and one of the many things that don’t make sense about Gossip Girl’s reboot is the revelation of GG’s new identity as well as its timing. Surprisingly, the new incarnation of Gossip Girl was actually Constance teachers who stalked and exposed their students to make them line up, and this was revealed at the start of the reboot.

It was very different from how Dan’s identity as Gossip Girl was revealed right at the end of the original show, and whether audiences like it or not, a student behind the website was much more. credible. The mystery and suspense that are the key to the series have not existed since GG’s identity was discovered so early.

6 The level of explicit

Chuck and Blair kiss in front of everyone at the Saints and Sinners party

Raising the eyebrows, especially those of the parents, is something that both versions of Gossip Girl do, but there is certainly a difference in the degree of explicit and nudity in the two shows.

RELATED: 10 Best Gossip Girl Couples & Their Most Iconic Scene

The original series was meant to shock with suggestive content and steamy scenes, but since it was on a network TV it always kept things PG – that’s not the case with HBO’s version of Max. Being on a paid streaming platform gives creators the ability to add a lot more free sex scenes as well as f-bombs, one of which includes a cruise to a public bath.

5 Social media representation

What to expect from the Gossip Girl season 1 part 2 reboot

In the age of texting, Blackberries and long before Instagram, Dan GG’s website portrays a primitive form of social media that he used to uncover scandals, but also to expose people’s sexuality against their will, to talk about their sex life and harass them in general. .

The reboot was developed firmly in the age of social media, and everyone already knows what everyone else is doing. So the original GG blog has turned into an Instagram account, and Gossip Girl tries to only reveal lies rather than humiliate people for their identity.

4 Litter of Gossip Girl

Chuck and Blair in Gossip Girl Season 1

Eagle-eyed viewers would notice a slight change in Gossip Girl’s address to the public – she no longer speaks only to the Upper East Side, and the students of Constance and St. Judes do. are not its only targets.

RELATED: A Quote From Every Gossip Girl Character That Sums Up Their Personality Perfectly

Kate Keller’s GG tells all about the city’s other schools, and not just the upscale Manhattan neighborhoods. This was mostly done to avoid getting caught, but it also shows that Gossip Girl is covering more ground because it’s a lot easier in today’s digital age.

3 Increased sensitivity to social issues

Aki and Audrey look at each other while holding their phones in Gossip Girl.

It’s safe to say that 2007 was a different time and the show reflected the lack of awareness in its writing and plots. Things that would be unacceptable today like forcing someone out of the closet, talking publicly about the first time someone has sex, and bitches getting to shame were common on the original. Gossip Girl, and the portrayal of LGBTQ + people was often symbolic and superficial.

The show’s developers changed that by treating social issues more sensitively and portraying the queer community in the right light. The Gossip Girl reboot shines a light on things like influence and cancellation culture, mental health, and other topics that the new generation is more aware of today.

2 Tickling between teenagers

Jenny Humphrey Blair Waldorf Season 1

Blair and Serena were known for the enemy relationship they shared, and Blair was no stranger to plotting, plotting, and taking people down. Serena has also had her fair share of catty scrapping, as has Chuck, who didn’t let anyone get in her way. The world of the original Gossip Girl was ruthless, but the reboot reduces that somewhat.

Teens are much more mature and even if they criticize themselves, it usually ends with them realizing their mistake and apologizing. For example, Julien made fun of Zoya several times during the reboot, but she always reconciled with her sister in the end. Sorry was much harder to find in the days of Blair, Serena and co.

1 The fashion

A shared image of Zoya, Julien, Monet and Luna, and Audrey.

Fashion has always been a big part of the show, and the Gossip Girl reboot offers incredible outfits. Both versions of the series pride themselves on showing off the character’s unique styles, but the fashions of both reflect the era in which they were created. The first students of Constance and St. Jude had closets full of colorful leggings, ballet flats, massive bags and tons of headbands.

Athleisure, second-hand vintage clothing, androgynous fashion, cycling shorts and sneakers dominate the Gossip Girl restart as these are currently trending styles. While fashion is key in both, the different styles are one of the most notable distinctions between the two shows.

NEXT: Which Gossip Girl Reboot Character Are You, Based On Your Zodiac Sign?

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BNY Mellon Wealth Management’s Kirti Naik on Growth Driven Digital Transformation + The Importance of Data-Driven Alliances https://replicachristianlouboutinstore.com/bny-mellon-wealth-managements-kirti-naik-on-growth-driven-digital-transformation-the-importance-of-data-driven-alliances/ Sun, 21 Nov 2021 18:00:00 +0000 https://replicachristianlouboutinstore.com/bny-mellon-wealth-managements-kirti-naik-on-growth-driven-digital-transformation-the-importance-of-data-driven-alliances/ More than ever, as marketing continues to be at the forefront of digital transformation, the function must work aggressively to move from being a cost center to being a true engine of growth. For this to happen, many critical organizational changes must take place, ranging from cultural changes, to building information infrastructures for better measurement, […]]]>


More than ever, as marketing continues to be at the forefront of digital transformation, the function must work aggressively to move from being a cost center to being a true engine of growth. For this to happen, many critical organizational changes must take place, ranging from cultural changes, to building information infrastructures for better measurement, to closer alignment between the different functional roles of the C-Suite.

With that in mind, I wanted to speak to a digital innovator known for his data-driven transformation strategies that drive growth. I recently spoke with Kirti Naik, Global Head of Marketing and Communications for BNY Mellon Wealth Management. She is a digital marketing pioneer and growth strategist with years of experience with major financial brands such as OppenheimerFunds (now Invesco), Russell Investments and Citibank. We’ve talked about everything from the ever-changing marketing landscape to the need to always identify ways to help grow the business, even after benchmarks are met. Here’s a summary of our conversation:

Billee Howard: Nice to talk to you Kirti. For a year and more, you have assumed your role as a leader in digital transformation at BNY Mellon Wealth Management. Tell me about your journey and the process that led to it, please.

Kirti Naik: First of all, thank you for inviting me and our brand to have this discussion. I joined during a very complex time. The pandemic had really just taken hold of the world and the US market, and I started in July 2020. Our business was going through a major transformation at that time and the role of marketing very quickly became quite relevant to the organization. in terms of Wealth. Management. As an industry, these are high quality premium experiences. It all depends on how we interact with each other in person. Marketing before the pandemic hit was really seen as a service and a support function. When I joined us, we had just started to look to virtual events, looking at how to do it best, how to implement it and how to get customers to participate? Because events were really at the heart of what marketing did to support the wealth management business, the obvious question was how can this be online?

I quickly read the situation and saw that we weren’t really taking advantage of all the different channels available to marketing to add value. We not only pivoted to virtual events, but we also had to look at this new proprietary framework and platform that was being rolled out in the market and called “”Active wealth. ‘ It is about applying the right framework to build, perpetuate and develop your wealth strategy. This is really important because there are five key practices in the process: investing, borrowing, spending, managing your taxes and expenses. Also, how do you protect your assets and your legacy? I was looking at this frame and thought it was great that we were turning to virtual events because it’s a great platform for us to do that. But, how can we actually connect with our customers and educate them? We’ve really changed our entire strategy from being much more of an on-demand warranty center, to a digital experience that allows us to help clients identify key strategies that are going to help move business forward.

Howard: You and I recently talked about best practices for CMO / CTO alignment and building a data driven organization. In fact, you mentioned that you established a close relationship with your CTO from day one. Tell me more.

Naik: I come from a digital marketing training. I was doing digital even before it was considered a wagering requirement in most brands. Because of my story, it was really important for me to start day one and identify who are the people who are driving this business forward in terms of data, technology, information and data collection. I really integrated into the processes my CTO and CIO were building for wealth. I knew right away that I wanted marketing to partner with them first and foremost to uplift what they were already doing, but also work to identify solutions to move the business forward.

It was really important that marketing did not work in a vacuum, and I spent many weeks with them, not only from an operational and financial point of view, but collaboratively, it would allow us to work together to have gains. fast in the short term. , but also build a long-term strategy. In the first three months of arriving and aligning with the right digital and tech players, we were able to create a business case for investing in marketing technology, as well as getting the right kind in place. support structure so that I can start rotating our organization to absorb digital. You can’t do it alone as a marketer, you need the help of operations and technology to bring your ideas to life. We have actually increased that mandate tenfold this year and are now working hand in hand with the same elements to build towards 2022 and beyond.

Howard: That’s a great answer, and I think it will be very informative because a lot of people struggle with a lot of what you’re talking about. With that in mind, I’d like your take on another big challenge right now: moving from the personalized to the individualized, in a way that accommodates business intimacy. Can you tell me what you think?

Naik: If one segment requires individualization, it is the ultra-high net worth segment. They are very, very important investors in our market. These are people who run businesses, create jobs, donate to charities, start up and give grants to those in need. It is a very important population that we not only serve, but with which we also collaborate in various capacities. We have to be very careful and judicious in our process and approach to make sure that we are still very delicate and surgical in the way we promote ourselves and our offerings. Digital technology allows us to do this in a very concerted and evolving manner. Now what I mean by that is it’s not about going out and just putting banner ads all over the internet or throwing emails for no reason.

It’s really about taking elements of behavioral targeting and collecting that data in a meaningful way. It’s about applying some of these algorithm-based data elements and then actually identifying the overlapping needs of those constituents and personalities. We also work in very close partnership with sales. The way we’ve done it is really to partner closely with the client-facing strategist, the wealth managers, complementing them to help them open the door to creating meaningful interactions. That’s where I think the power comes in. It’s not in the micro segmentation, or the spray and prayer model. There is a balance needed between the two to approach your clients so that it is truly personalized and they feel that we can advise them on what they need most, at the right time.

Howard: Finally, we discussed the shift of marketing from a cost center to a hypergrowth engine. Tell me about the best practices around this idea, especially since you’ve used marketing to bring in a lot of assets since you took office.

Naik: I think marketing has always been seen as a complement to visibility, generally speaking, and in particular the wealth management industry has undergone a massive transformation, as a sector of the larger financial services industry. Wealth management companies need to be able to embrace the skills of the new age. These include technology, social dynamics, new ecosystem players and even the rise of different digital channels and assets. We need to understand that the investor population is changing rapidly. We have the Baby Boomers and Generation X, but now we also have Generation Y and Generation Z. They all have different needs. Yes, it is essential that we really understand who we are talking to and what we want to offer them. Frankly, marketing should be one of the most powerful business levers to generate measurable hyper growth.

To achieve this vision, we began to identify mechanisms for number one, measuring the effectiveness of what we still do. This is the first rule of thumb that I introduced in every organization. You have to prove your worth and you do it by driving strategy. Second, how do you equip the field, the sales teams with new opportunities? It absolutely always has to be about that part of it. People have often told me that in B2B marketing cannot generate leads. It’s ridiculous. Yes, we should help you with all the tools you need, your various media, but marketing should do a lot more than that. I think it’s up to us as marketers to figure out how to create the demand. Third, I think it comes down to the customer experience. We need to empower those in contact with the customer and really increase the value of online experiences. Therefore, we always have to think about how we leverage traditional owned and acquired digital, all the different channels available to us to deliver the best customer experience.

At BNY Mellon Wealth Management, a recent and powerful example that I can share to demonstrate how we have leveraged all of these channels is the launch of our Active wealth accelerator. It is a commercially available, interactive, educational and immersive platform. The Active Wealth Accelerator is a mobile and desktop experience, easily shareable via a QR code and intended for potential clients to help them assess their wealth strategy through a series of 15 questions related to our five Active Wealth practices. Based on the responses, a personalized recommendation is presented, showcasing the strengths and opportunities of the investor through Active Wealth, and promoting the relevant content to help unlock their financial potential. The value of the tool is that it helps individuals better understand their wealth needs, as well as ask the right questions of themselves and their advisers ultimately.



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Rainbow knits have a moment – here’s how to keep up with the trend https://replicachristianlouboutinstore.com/rainbow-knits-have-a-moment-heres-how-to-keep-up-with-the-trend/ Sat, 20 Nov 2021 07:00:56 +0000 https://replicachristianlouboutinstore.com/rainbow-knits-have-a-moment-heres-how-to-keep-up-with-the-trend/ A key point of the spring / summer 2022 fashion shows? Our knit drawers are ready for a colorful upgrade. Cool-girl brand The Elder Statesman provided the LA crowd with her rainbow sweaters: Hailey Bieber recently rocked her patchwork cardigan over The Attico’s cult zebra-print bikini, while Kendall Jenner donned a oversized sweater – and […]]]>


A key point of the spring / summer 2022 fashion shows? Our knit drawers are ready for a colorful upgrade. Cool-girl brand The Elder Statesman provided the LA crowd with her rainbow sweaters: Hailey Bieber recently rocked her patchwork cardigan over The Attico’s cult zebra-print bikini, while Kendall Jenner donned a oversized sweater – and a matching hat – from her fall / winter 2021 collection a fortnight ago.

EmRata advocates for tangy sweaters.

REAR-GRILLE

Victoria Beckham wears her own label colorful knitwear.

James devaney

Emily Ratajkowski and Victoria Beckham are also embracing the colorful knitwear movement. The first recently wore an acid-shiny turtleneck, while VB modeled a bright red sweater and sun-yellow pants from his own collection, joking on Instagram that Ronald McDonald “stole [her] see. ”Rihanna, meanwhile, took to lavender hues, including a knit cardigan from London designer Martine Rose, and Beyoncé showed the potential of colorful knits as an evening dress with a ribbed knit bodysuit. tangerine from Area.

Jacquemus’ Spring / Summer 2022 collection featured vitamin C knits.

Passionate knitter Gabriela Hearst made her debut with handcrafted pieces for Spring / Summer 2022.

The street gang cemented the trend outside of the SS22 catwalks, with the catwalks reflecting their fashion playful mood: Gabriela Hearst, Blumarine, Molly Goddard, Altuzarra and Acne Studios all made their cheery knit debuts. The trend is also felt on Depop; all it takes is a search to discover the multitude of home options available. Mia Regan is a strong advocate for supporting lesser-known brands: influencer Gen-Z has a wardrobe full of living, artisanal products.

Our advice: be bold and bright in your knitwear choices this winter.

Arket alpaca and merino cardigan

Jacquemus The Twisted Cardigan

AGR striped cable-knit wool sweater

Missoni sleeveless zigzag-knit top

Victoria Beckham open-knit alpaca-blend turtleneck sweater

The Elder Statesman lantern-sleeve cashmere cardigan

Cos patch pocket cardigan

Miu Miu garter stitch wool cardigan

Acne Studios marl-knit sweater

Image may contain: Clothing, Sleeve, Clothing, Long Sleeve, Human and Person

17 dopamine sweaters you won’t want to take off this fall



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Light-skinned people wear blue clothes the most, study finds https://replicachristianlouboutinstore.com/light-skinned-people-wear-blue-clothes-the-most-study-finds/ Thu, 18 Nov 2021 16:24:09 +0000 https://replicachristianlouboutinstore.com/light-skinned-people-wear-blue-clothes-the-most-study-finds/ Forget the little black dress! People with fair skin are best suited for BLUE clothes, while people with tanned skin tones should go for orange, study finds Scientists Asked Volunteers to Choose Clothing Colors Suitable for Different Skin Types Results suggest that skin tone may determine color preferences for our clothes This may be due […]]]>


Forget the little black dress! People with fair skin are best suited for BLUE clothes, while people with tanned skin tones should go for orange, study finds

  • Scientists Asked Volunteers to Choose Clothing Colors Suitable for Different Skin Types
  • Results suggest that skin tone may determine color preferences for our clothes
  • This may be due to a link made between warmer climates and darker skin tones.










If you often struggle to decide what to wear, a new study suggests you should take inspiration from your skin tone.

Scottish researchers have found that people with fair skin are considered better suited to blue clothes, while people with tanned skin are said to look better with “warm” orange and red hues.

Fashion stylists and salespeople tend to recommend clothing colors to complement a customer’s personal appearance, such as a blue dress for a person with pale skin.

Now the new study is finally offering scientific evidence to show that it is indeed considered interesting in the eyes of observers, like a partner on a first date.

In the experiments, people with fair skin (left) were found to be better suited to blue clothing, while people with more tanned skin (right) were expected to look better with “warm” orange and red hues, report experts from the University of St Andrews.

COLORS AND THEIR ASSOCIATIONS

Red: caution, anger, love, warmth

Orange: warm, autumn

Yellow: happy, fun, young

Green: nature, calm, good luck

Blue: stability, professional, cold, confidence, intelligence

Purple: wealth, mystical, decadent

Brown: rustic, practical, warm, vintage

White: sterile, innocence, peace, truth, cleanliness

Black: sophistication, death, night, contemporary

Source: ONS

“Clothing is important for self-esteem and psychological health,” said study author Dr Reiner Sprengelmeyer of the University of St Andrews.

“The global fashion industry is worth billions of dollars and color is a major factor in the choice of clothing. So it’s important to find rules that help people be their best.

For the study, the team recruited 160 participants to give their opinion on which colors would suit different faces in the photos.

The researchers used 12 facial images of white women captured under standard lighting – six with fair skin and six who were more tanned.

The measurements confirmed that the tanned group had darker, yellower skin, reflecting higher levels of melanin, a skin pigment.

Human skin color differences are mainly based on melanin, but also hemoglobin – the protein found in red blood cells – and carotenoid pigments.

Using custom software, participants could change the color of the simulated clothing to suit each of the 12 target faces.

“We gave attendees a wide array of colors to choose from,” said lead author Professor David Perrett.

‘In addition, colors could be adjusted in brightness or saturation (vividness).’

Participants were asked to match different faces to the color they thought best matched the person's skin tone using special software.  Participants could choose any color displayed in a rectangular rainbow (pictured)

Participants were asked to match different faces to the color they thought best matched the person’s skin tone using special software. Participants could choose any color displayed in a rectangular rainbow (pictured)

Despite the full range of shades available, participants tended to focus their choice on blues and reds or orangey reds.

Overall, 75% of participants thought blue tints looked better on fair-skinned women and similarly 75% thought oranges / reds looked better on darker-skinned women.

“To our surprise, the public also agreed on which colors looked best with which skin tone,” said Professor Perrett.

The study claims to provide the first scientific evidence that skin tone is a basis for color aesthetics in clothing.

The presence of melanin - a pigment responsible for the color of the skin - causes the skin to darken

The presence of melanin – a pigment responsible for the color of the skin – causes the skin to darken

One possible explanation for the results is an association in people’s minds between warm climates and a darker complexion, and conversely between cool northern climates and a fair complexion.

People subconsciously associate “cool” (blue) colors with a cool climate and therefore may choose blue for people with fair skin, while red is associated with warmth.

Future research should examine the color of clothing against a full range of melanin levels defined using spectrophotometry – a technique that uses different wavelengths of light.

The study was published in the journal Perception / i-Perception.

SCIENTISTS FIND NAVY THE MOST RELAXING COLOR, BUT TURQUOISE AND PASTEL ROSE HELP BEAT STRESS

Navy blue is the most relaxing color, according to a 2019 study.

Researchers at the University of Sussex said surrounding yourself in blue clothes, objects and accessories could help you lead a more relaxed life.

Calm is mostly inspired by dark blues, turquoises, and pinks, while luxury colors include purple, orange, and white.

The researchers asked 26,596 people from over 100 countries to name their favorite color. They then determined which word they most associate with that shade.

Some of the most common words related to colors were happy, followed by calm, bright, warm, sky, sea, cool, vibrant, and summer.

Specifically, the survey found that globally, people associate “strong” colors with undertones of blue, red and orange.

The calm most inspired by dark blues, turquoises and pinks, while notions of the future were most often associated with shades of green.

Luxury colors included purple, orange, and white.





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Research could lead to a plethora of drug targets – ScienceDaily https://replicachristianlouboutinstore.com/research-could-lead-to-a-plethora-of-drug-targets-sciencedaily/ Wed, 17 Nov 2021 00:34:59 +0000 https://replicachristianlouboutinstore.com/research-could-lead-to-a-plethora-of-drug-targets-sciencedaily/ Researchers at UT Southwestern and the University of Washington led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions. The study, published in Science, identified for the first time more than 100 probable protein complexes and provided structural models for more than 700 previously uncharacterized […]]]>


Researchers at UT Southwestern and the University of Washington led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions. The study, published in Science, identified for the first time more than 100 probable protein complexes and provided structural models for more than 700 previously uncharacterized complexes. Information on how pairs or groups of proteins fit together to effect cellular processes could lead to a host of new drug targets.

“Our results represent a significant advance in the new era of structural biology in which calculus plays a fundamental role,” said Qian Cong, Ph.D., assistant professor at the Eugene McDermott Center for Human Growth and Development with a secondary position. in biophysics. .

Dr Cong led the study with David Baker, Ph.D., professor of biochemistry and postdoctoral mentor to Dr Cong at the University of Washington prior to his recruitment at UT Southwestern. The study has four lead co-authors, including UT Southwestern computational biologist Jimin Pei, Ph.D.

Proteins often work in pairs or groups called complexes to perform all the tasks necessary to keep an organism alive, Dr. Cong explained. While some of these interactions are well studied, many remain a mystery. Building complete interactomes – or descriptions of the full set of molecular interactions in a cell – would shed light on many fundamental aspects of biology and give researchers a new starting point for developing drugs that either encourage or discourage such interactions. interactions. Dr Cong works in the emerging field of interactomics, which combines bioinformatics and biology.

Until recently, a major obstacle to building an interactome was the uncertainty about the structures of many proteins, a problem that scientists have been trying to solve for half a century. In 2020 and 2021, a company called DeepMind and Dr. Baker’s lab independently released two AI technologies called AlphaFold (AF) and RoseTTAFold (RF) that use different strategies to predict protein structures based on gene sequences that produce them.

In the present study, Dr Cong, Dr Baker and their colleagues developed these AI structure prediction tools by modeling numerous yeast protein complexes. Yeast is a common model organism for basic biological studies. To find proteins that could interact, the scientists first searched the genomes of related fungi for genes that had acquired mutations in a related manner. They then used the two AI technologies to determine if these proteins could be assembled into 3D structures.

Their work identified 1,505 probable protein complexes. Among these, 699 had already been characterized structurally, verifying the usefulness of their method. However, there was only limited experimental data supporting 700 of the predicted interactions, and another 106 had never been described.

To better understand these poorly characterized or unknown complexes, teams at the University of Washington and UT Southwestern worked with colleagues around the world who were already studying these or similar proteins. By combining the 3D models that the scientists in the present study had generated with the information from the collaborators, the teams were able to acquire new knowledge about the protein complexes involved in the maintenance and processing of genetic information, cell construction and transport systems, metabolism, DNA repair and other places. They also identified roles for proteins whose functions were previously unknown based on their newly identified interactions with other well-characterized proteins.

“The work described in our new article sets the stage for similar studies on the human interactome and could potentially help develop new treatments for human diseases,” added Dr. Cong.

Dr Cong noted that the complex predicted protein structures generated in this study can be downloaded from ModelArchive (https://modelarchive.org/doi/10.5452/ma-bak-cepc). These structures and others generated using this technology in future studies will be a rich source of research questions for years to come, she said.

Dr Cong is a Southwestern Medical Foundation Fellow in Biomedical Research. Other UTSW researchers who contributed to this study include Jing Zhang and Josep Rizo, Ph.D., Virginia Lazenby O’Hara Chair in Biochemistry.

Collaborating institutions include: Harvard University, Wayne State University, Cornell University, MRC Laboratory of Molecular Biology, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Fred Hutchinson Cancer Research Center, Columbia University, University of Würzburg in Germany, St Jude Children’s Research Hospital, FIRC Institute of Molecular Oncology in Milan, Italy, and National Research Council, Institute of Molecular Genetics in Rome, Italy.

This work was supported by the Southwestern Medical Foundation, the Cancer Prevention and Research Institute of Texas (CPRIT) (RP210041), Amgen, Microsoft, the Washington Research Foundation, Howard Hughes Medical Institute, National Science Foundation (DBI 1937533), National Institutes of Health (R35GM118026, R01CA221858, R35GM136258, R21AI156595), UK Medical Research Council (MRC_UP_1201 / 10), HHMI Gilliam Fellowship, Deutsche Forschungsgemeinschaft (KI-562 / 11-1, KI-562 / 7-1), researcher of the AIRC and Research Council Consolidator (IG23710 and 682190), Defense Threat Reduction Agency (HDTRA1-21-1-0007) and National Energy Research Scientific Computing Center.



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In The Style founder retires as CEO of online fashion retailer https://replicachristianlouboutinstore.com/in-the-style-founder-retires-as-ceo-of-online-fashion-retailer/ Fri, 12 Nov 2021 10:51:38 +0000 https://replicachristianlouboutinstore.com/in-the-style-founder-retires-as-ceo-of-online-fashion-retailer/ R Newly launched online fashion retailer In The Style has revealed that its founding entrepreneur Adam Frisby will take a step back as CEO. The 34-year-old steered his startup into an IPO in March, seeing it float on AIM at 200p per share. Frisby is now estimated at over £ 35million. In a surprise gesture, […]]]>


R

Newly launched online fashion retailer In The Style has revealed that its founding entrepreneur Adam Frisby will take a step back as CEO.

The 34-year-old steered his startup into an IPO in March, seeing it float on AIM at 200p per share. Frisby is now estimated at over £ 35million.

In a surprise gesture, the founder announced today that he has decided to now work in a newly created position at the board level of brand director.

In The Style is known for its collections with reality TV stars, and Frisby will continue to develop influencer partnerships and oversee the brand’s creative direction in the new role.

Former CEO of The Very Group and former CEO of Tesco, Sam Perkins, will take the reins as CEO of the group from January 17.

Frisby praised Perkins’ experience in business development and said: “With the scale of the business that we are today and with the many growth opportunities we must seek, I felt that the time has come to further strengthen our leadership team. “

The non-executive chairman of the retailer, Jim Sharp, said the couple “will form a formidable partnership to advance the continued expansion of the brand.”

Sharp said Perkins being CEO “will also allow Adam to focus his energy and talent” on the new brand role.

Independent retail analyst Nick Bubb said the “struggling” online fashion industry’s move came “out of the blue”.

The retailer has seen its shares almost in half since mid-September and recently warned of earnings due to supply chain disruption and a higher rate of return.

Liberum analysts said: “The appointment of a new CEO brings substantial benefits to the group. This gives Adam Frisby the time and opportunity to focus on his core skills of managing the growing influencer base of the group, the product, and all that is creative. at the same time, the new CEO brings a wealth of operational experience – something ITS needs as it continues its rapid growth trajectory. “



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Bottega Veneta and Daniel Lee go their separate ways, shocking the fashion world https://replicachristianlouboutinstore.com/bottega-veneta-and-daniel-lee-go-their-separate-ways-shocking-the-fashion-world/ Wed, 10 Nov 2021 18:49:33 +0000 https://replicachristianlouboutinstore.com/bottega-veneta-and-daniel-lee-go-their-separate-ways-shocking-the-fashion-world/ The fashion world is in shock at the kind of punchy ad it hasn’t received in some time. Creative Director Daniel Lee is stepping down from his role at Bottega Veneta even as he has transformed the house into, arguably, the liveliest house in all of fashion since taking charge in mid-2018. An official press […]]]>


The fashion world is in shock at the kind of punchy ad it hasn’t received in some time. Creative Director Daniel Lee is stepping down from his role at Bottega Veneta even as he has transformed the house into, arguably, the liveliest house in all of fashion since taking charge in mid-2018. An official press release from parent company Kering describes the move as a “joint decision to end their collaboration.”

“My stay at Bottega Veneta was an incredible experience. I am grateful to have worked with an exceptional and talented team and I am eternally grateful to everyone who was involved in creating our vision, ”said Lee in an included statement.

To say the announcement was unexpected was an understatement. Bottega Veneta just put on a hit show in Detroit last month and has regularly released a series of must-have accessories. Handbags like the mini Jodie, clutch and cassette have all become the kind of “It” bags just as likely to be found on the arms of high powered fashion editors as they were Instagram influencers. The brand’s Tire boots had become a unisex staple, and the clothing found fans with everyone from Tracee Ellis Ross to Selena Gomez. Lee’s influence within the brand has reached such a point that it is now impossible to step into a Zara or an H&M without seeing distinct echoes of Bottega. Many in the fashion press viewed his work as the spiritual successor to Phoebe Philo’s beloved run at Celine (in fact, Lee worked under Philo at the French house). Even when the brand notoriously deleted its Instagram page, it only added to the buzz.

Photographed by Serichai Traipoom

The Italian brand, known for its distinctive ‘Intrecciato’ braided leather pattern, has always been featured on the shelves of top department stores, but for most of its history it has adhered to a ‘wealthy’ approach to fashion. stealth “(or” coded luxury “). . The brand would never have dreamed of affixing a logo on the outside of its clothes or accessories. Lee had managed to stay true to the house codes and its 55-year heritage, while producing instantly recognizable pieces that were both Bottega Veneta and yet something new, exciting and on-trend.

So why leave now? Well that’s what everyone is asking. We’re guessing there won’t be any hotter gossip at tonight’s CFDA Awards, where Lee is nominated for International Women’s Clothing Designer of the Year. The answer might be obvious if another more high-profile fashion house had an opening in its Creative Director’s office, but that just isn’t the case, right now anyway. We doubt that a designer coming out of such a successful career will remain unemployed for long.

Photographed by Serichai Traipoom

Not so long ago, creative directors would play a fashion musical chair tour every three or four years, parting ways with their respective houses relatively soon after being appointed to their posts. But that pace has slowed down somewhat recently, which only makes this particular announcement even more surprising.

For its part, Bottega specifies that a “new creative organization for the House will be announced soon”.



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Where to live for a better chance of income equality? Try Japan https://replicachristianlouboutinstore.com/where-to-live-for-a-better-chance-of-income-equality-try-japan/ Tue, 09 Nov 2021 03:00:07 +0000 https://replicachristianlouboutinstore.com/where-to-live-for-a-better-chance-of-income-equality-try-japan/ ~~ ~ Suddenly, inequalities are at the top of the political agenda almost everywhere, at least that is what it seems. US President Joe Biden aims to present tax proposals that “will make billionaires cry,” according to staunch supporter Senator Elizabeth Warren. In Britain, the Conservative government has taken taxes on GDP to new heights […]]]>


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Tokyo during COVID-19: Green spaces and the rise of telecommuting offer new lifestyle opportunities

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Suddenly, inequalities are at the top of the political agenda almost everywhere, at least that is what it seems. US President Joe Biden aims to present tax proposals that “will make billionaires cry,” according to staunch supporter Senator Elizabeth Warren.

In Britain, the Conservative government has taken taxes on GDP to new heights as part of Prime Minister Boris Johnson’s “leveling” program. Even the meritocratic Singapore is considering a wealth tax to promote social cohesion.

Surprisingly, Chinese President Xi Jinping is starting to look like a true Communist. The mega-rich tech oligarchs and posh celebrities became non-people overnight. Meanwhile, the government unveiled the concept of “common prosperity”, aimed at channeling money and resources to the less developed regions of the country.

Is the same drug compulsory in Japan? In his campaign for the leadership of the ruling Liberal Democratic Party in Japan, Prime Minister Fumio Kishida criticized “neo-liberalism” and claimed that there could be “no growth without redistribution”.

He won in that party election and then got a surprisingly strong result in the recent general election. It seems he “read the air” correctly. But did he understand the facts correctly?

A Runner Delivery Company in Amagasaki City, Hyogo Prefecture.

Measuring inequalities

Inequality is talked about a lot, but rarely put into context. The standard measure of income inequality is the Gini coefficient, named after Italian statistician Corrado Gini. It is usually expressed as a number between 0 and 1. 0 would mean a pure communist state where everyone gets the same income, while 1 would mean absolute absolutism where one person gets everything.

Most developed countries are between 0.25 and 0.40.

It is widely believed that the gap between rich and poor is widening in an unprecedented and disturbing way. Globally, this is far from the case. Zsolt Dargas of the Bruegel Group shows that the Global Gini peaked at a very high level of 66.9 in 1988, but then fell each year to 58.5 in 2017.

However, when you divide the world into countries and weight them based on their population size, you get a very different answer. The average Gini of the world in fact mounted in this period – from a much lower level.

Two huge developing countries, China and India, have grown rapidly, narrowing the income gap with richer countries. But within these two countries, inequalities have increased as they have moved from a situation of “everyone poor” to one in which entrepreneurs and business leaders have emerged and increased their incomes a lot. more than the average person.

Given that the policy is conducted on a national basis, it is not surprising that income inequality within countries receives much more attention than the more encouraging global picture.

According to Forbes magazine, China and the United States together account for half of the world’s 2,755 billionaires. Unsurprisingly, both boast high Gini scores. In the case of China, such politically sensitive data is not readily available, but the Central Intelligence Agency estimates a Gini of 46.5 – not much different from the notoriously uneven Brazil. The United States sits at 0.390, a high for a wealthy country, but not off the charts. In either case, the political momentum towards a flatter distribution is easy to understand.

What about Japan? In 2017, the Gini income was 0.33, higher than that of European social democracies, but lower than that of Israel, South Korea, United Kingdom, United States and Mexico among the countries of the Organization for Economic Co-operation and Development.

Importantly, there is no evidence that inequality increased during the Abenomics era from 2013. On the contrary, income inequality in Japan was slightly lower in 2017 than at the turn of the century. The real damage was done earlier, in the miserable years following the collapse of the economic bubble. Bad times hurt the poor more than the rich.

It is important to note that the gross Gini coefficient, before adjustment for taxes and social insurance, Is show that inequalities are increasing year by year, from 0.47 in 1999 to 0.56 in 2017. In other words, Japanese government policy has succeeded in suppressing a strong trend of income inequality. The amount of redistribution increases year by year, effectively blocking the results of the “neoliberal” market.

Other measures tell a similar story. According to United Nations data, the ratio of the average income of the richest 10% in Japan to the poorest 10% is 4.5 times. This is the lowest ratio of all the countries in the database.

Actual deprivation is difficult to define, but the Ministry of Health, Labor and Welfare puts the number of homeless people in Japan at 3,992, while charities estimate that on a broader definition, the number would be two or three times higher.

To give an idea, the Shelter homeless charity estimates that there are 280,000 people in the UK who have nowhere to live. The majority are housed in temporary facilities, but 24,000 sleep on the streets or in cars, sheds, abandoned buildings, etc. In the United States, the estimate of the homeless is 553,000, of which 192,000 sleep in places not intended for human habitation and 40,000 are former military veterans.

If you are poor you would be better off in Japan than in many other countries.

Tadashi Yanai, one of the richest people in Japan, built his business on egalitarian fashion.

What about the wealth gap?

Most of the income goes through the tax system, so the information needs to be reliable. Wealth, which is much harder to track, is much more important.

Three academics – Professor Anthony Horrocks from the University of Manchester, Professor James Davies from the University of Western Ontario and Dr Rodrigo Lluberas from the Central Bank of Uruguay – made a Herculean effort to build global Gini wealth, which is published in the latest edition of Credit Suisse’s Global Wealth Report. They included property as well as financial assets in the calculation.

Their findings are that both within countries and globally, wealth is much more unequally distributed than income. Thanks to the extraordinary changes in China and India, the global Gini has declined somewhat this century, but almost all of the 10 largest economies have seen an increase in wealth inequality.

The two exceptions are Germany and Japan. On these metrics, the claim that “the Abenomics have widened the gap between the rich and the poor” just doesn’t match.

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In addition, Japan has by far the lowest Gini wealth: 64.4, compared to 85 for the United States and 77.9 for Germany. The same goes for the share of wealth held by the richest 1%. In Japan, it is 18%, compared to 35% in the United States and 29% in Germany.

In other words, when it comes to wealth, Japan has a much more even distribution than major European countries, let alone the United States and China.

Like most countries, Japan faces many economic and social challenges. The figures show that excessive neoliberalism is far from a major concern and that inequalities are low on many key parameters.

Today, Japan is in a good position, in part thanks to the success of the Abenomics. And Prime Minister Kishida has a great opportunity to extend the winning streak.

RELATED: Fumio Kishida: Japan’s New Prime Minister Elected To Work For Economic Recovery And Equality

Author: Peter Tasker



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Brooklyn Beckham lands £ 1million contract to be the face of streetwear label Superdry https://replicachristianlouboutinstore.com/brooklyn-beckham-lands-1million-contract-to-be-the-face-of-streetwear-label-superdry/ Sun, 07 Nov 2021 04:57:43 +0000 https://replicachristianlouboutinstore.com/brooklyn-beckham-lands-1million-contract-to-be-the-face-of-streetwear-label-superdry/ David and Victoria’s oldest son Beckham has landed a new contract to be a model for the High Street brand – and will throw a party at the London flagship store next week. Video upload Video unavailable The video will soon play automatically8to cancel Play now Brooklyn Beckham and Nicola Peltz kiss on Instagram Brooklyn […]]]>


David and Victoria’s oldest son Beckham has landed a new contract to be a model for the High Street brand – and will throw a party at the London flagship store next week.

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Brooklyn Beckham and Nicola Peltz kiss on Instagram

Brooklyn Beckham landed an exceptional payment by landing a modeling job with the street clothing company Superdry.

The 22-year-old former photographer decided to step in front of the camera for a change – and cash in a good million for his efforts.

Brooklyn shot a new campaign for the British streetwear brand – with himself posing with his tattooed chest exposed under an open outer jacket.

He’s also hosting a party with the brand in London on Tuesday night where Superdry’s new sustainable fashion line will be showcased.

A source said The Sun on Sunday: “This is a huge opportunity for Brooklyn and will cement it as a real name in the menswear world.








Brooklyn Beckham was awarded a £ 1million contract to be the face of Superdry
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“It’s a great gig for him to land and it allowed him to focus.

“He is also very committed to sustainable development, so he is delighted to invest in it. “

While a £ 1million paycheck might seem like a lot to most, it can be seen as small change for Brooklyn – who belongs to a family with enormous personal wealth.

Much has been said that famous parents David and Victoria Beckham have a fortune of £ 335million and live in a £ 6million second home in the Cotswolds.








Brooklyn is engaged to Nicola Peltz – the daughter of a billionaire
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As Dave sparked fury last month when it was discovered he had added to family wealth by agreeing to a £ 150million deal to be the face of Qatar’s World Cup despite the controversial country having a scandalous inequality of human rights.

Dave’s appointment – and his payment – have led to calls for him to be stripped of his title of UNICEF Goodwill Ambassador.

While the Mirror called their decision to accept a huge payment for Qatar’s controversial upcoming games “unforgivable”.



Meanwhile, Brooklyn makes sure he stays rich one way or another – by marrying even more money.

He is engaged to 26-year-old American model and actress Nicola Peltz – who is the daughter of a billionaire businessman and invested 79-year-old Nelson Peltz.

Brooklyn and Nicola are already the face of Pepe Jeans – making his new contract with Superdry his latest effort to follow in his father’s footsteps.








Brooklyn and Nicola are currently the face of Pepe Jeans
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Brooklyn recently helped Nicola decide which Pepe Jeans products to wear
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The engaged couple shared photos and videos via social media supporting the jeans brand.

A recent video showed Brooklyn deciding what outfit his fiancee should wear – choosing a little black dress for her that he said would be “pretty” to wear.

Speaking about his future wife in a recent post, Brooklyn wrote: “The last few years have been the best years of my life x you make me smile and laugh every day. I am the luckiest person in the world to be able to spend the rest of my life with you xx 2 forever i love you nicola. “


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Israel’s wealth attracts high-end watch brands https://replicachristianlouboutinstore.com/israels-wealth-attracts-high-end-watch-brands/ Fri, 05 Nov 2021 04:00:56 +0000 https://replicachristianlouboutinstore.com/israels-wealth-attracts-high-end-watch-brands/ Israel may be a small country – with fewer people living there than London – but its watch market is surprisingly lucrative. Exports of Swiss watches to Israel rose 4.1% to 52.6 million Swiss francs ($ 57.1 million) between January and August of this year compared to the same period in 2019, according to the […]]]>


Israel may be a small country – with fewer people living there than London – but its watch market is surprisingly lucrative.

Exports of Swiss watches to Israel rose 4.1% to 52.6 million Swiss francs ($ 57.1 million) between January and August of this year compared to the same period in 2019, according to the Federation. of the Swiss watch industry.

Meanwhile, luxury watch brands began to settle there. Hublot announced its first concession at the Impress watch and jewelry store in the port city of Haifa, 18 months after opening its own first boutique in Tel Aviv. Audemars Piguet, one of the world’s largest private independent watchmakers, opened an AP house in Tel Aviv last month. The store is located in the city’s financial district, where an apartment in the 32-story Rothschild 1 tower can cost Shk 50 million ($ 15.6 million).

“Israel is one of the most interesting countries in my region [whose] The market is much larger than it appears, ”says Augusto Capitanucci, regional director of Hublot. The brand’s sales have grown by double digits year-over-year in Israel since he started his post in 2015. The numbers for 2021 are now back to the same level as 2019 sales, as there are rebounded faster in Israel after the first lockdown than in its other territories.

Reginald Brack, a US-based watch industry analyst, compares Israel’s watch market to that of St. Barts, Monaco or Hong Kong. “I don’t think size matters as much as concentration of wealth,” he says of the billionaires, millionaires and tech entrepreneurs who make up Israel’s clientele. “These are more frequent return buyers than you might think.”

Israel has one of the highest billionaire per capita ratios in the world and a growing tech sector that attracts foreign buyers, creating many “sudden” local millionaires, says the diamond industry analyst, Edahn Golan.

However, Panerai chief executive Jean-Marc Pontroué believes his brand’s business with Israelis living or traveling abroad is far more important than business done inside the country. Its daily sales figures by nationality show that Israelis regularly shop in stores around the world.

He adds that tax refunds make Panerai’s standardized global prices more affordable because in Israel imported watches are subject to a 17% tax.

Worn as status symbols, Rolex, Omega or Patek Philippe watches are among the most collectable in Israel, says Herzliya-based vintage watch dealer Nimrod Kozik. The same is true of “everything military,” he adds – in a country where conscripts are traditionally given a watch before their service in the Israel Defense Forces.

Local spending has soared to a six-figure average when “it used to be like four figures,” says Jonasoff of JB Jewelers, who sees increased demand for more exclusive pieces.

Location matters, Tel Aviv being at the forefront as a hub of luxury, fashion and business. “[In] Jerusalem, most customers are Jewish tourists [from America, Europe, Russia and elsewhere] who visit once or twice a year, so they are regular customers, ”explains Jonasoff, whose boutiques are located in Tel Aviv’s luxury fashion district, Kikar Hamedina, and near the famous King David Hotel in Jerusalem.

Haifa and Eilat are also popular watch buying destinations, says Jaffa-based watchmaker Itay Noy, who also lectures on watch movements at the Bezalel Academy of Arts and Design in Jerusalem. “Haifa is the capital of the north, so all the people of the north would go to Haifa and not Tel Aviv,” says Noy. The appeal of Eilat, Israel’s southernmost city, is its 17% VAT exemption, which makes it popular with tourists.

Analyst Brack says interest in Israel is a natural evolution of big brands – such as Rolex, Patek Philippe and Audemars Piguet – looking to tap into watch markets that are not yet saturated, like those in the United States and from Europe.

“All of these brands are constantly looking to see [where is the] white space in retail, what are we missing, ”he says. “Where are there other markets that we can sell? “



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